All you need to know about exosomes and microneedling (RF machine)

In the world of skincare and aesthetic advancements, the pursuit of skin rejuvenation and radiance continues to evolve. This article will delve into two transformative topics: Exosomes and Microneedling with RF machines.

From the intricacies of exosomes to the combination of microneedling with RF technology, we are here to guide you through these exciting and effective procedures.

What are exosomes?

Exosomes are a type of tiny extracellular vesicle originating from within cells. Measuring 30 to 150 nm in diameter, they are enclosed by a lipid bilayer and released into the area outside the cell – a process known as exocytosis. Exosomes carry a complex cargo derived from their parent cells. 

The complex cargo includes proteins, lipids, mRNA, miRNA and even DNA [1]. This means that exosomes have the unique ability to communicate their genetic information to other cells – near and distant. Hence, exosomes can target specific cells, transfer their content, and alter the characteristics of the recipient cell. 

Exosomes can be used in a plethora of treatments such as cancer therapy, tissue repair and regeneration, immunotherapy, therapeutic applications for diabetes and lung diseases, etc [2]. The list of treatment opportunities with exosomes is endless. 

In the realm of aesthetics, what this translates to is that exosomes can be used for encouraging cell regeneration in the skin and treating dermatological problems, thus resulting in skin renewal and rejuvenation [3].

Exosomes are released outside the cell in a process known as exocytosis.

What is microneedling with RF machines?

Microneedling with RF (radiofrequency) machines is an innovative skincare technique combining two effective skin rejuvenation treatments [4]. Ultra-fine needles are used to gently puncture the surface of your skin to stimulate your body’s natural healing process, improving skin texture once healed. RF technology uses warm energy that deeply penetrates your skin, stimulating collagen production, and tightening tissues.

Microneedling is a type of collagen induction therapy involving tiny needles to create micro-injuries in your skin, prompting collagen synthesis. When combined with RF energy, this process is enhanced. The RF energy heats the deeper layers of your skin, enhancing collagen remodelling, and giving your skin a smoother and tighter appearance [5]. This dual action addresses skin concerns such as fine lines, wrinkles, scars, and even sagging skin.

But you may be wondering, does microneedling with RF hurt?

Most procedures involve numbing cream, ensuring your comfort. After the treatment, your skin may be slightly red, but downtime is typically minimal, usually only for about an hour or two. This modern approach to skincare offers impressive results, helping you achieve a more youthful and revitalised appearance.

RF microneedling
Radiofrequency microneedling works by causing micro-injuries to the face to stimulate the body’s natural healing reaction – the production of collagen.

What does microneedling RF with exosomes do?

When you undergo microneedling with RF, the tiny needles create controlled micro-injuries in your skin. Your body then works to repair these “injuries” by stimulating collagen production for plumper, smoother skin. Exosomes follow this process by carrying instructions and materials that support healing and tissue regeneration. When applied during or after microneedling with RF, exosomes provide an extra dose of goodness, supercharging the rejuvenation process, and giving you renewed and rejuvenated skin [6].

Benefits of exosome-enhanced microneedling RF

A 2023 study showed that exosome-enhanced microneeding RF significantly improved skin hydration, elasticity, wrinkles, and pigmentation [7]. Additional benefits include:

  • Enhanced healing: exosomes boost your skin’s natural healing processes, helping to repair and rejuvenate faster.
  • Collagen supercharge: the combination of exosomes and microneedling with RF stimulates collagen production on a deeper level, improving your skin’s elasticity and firmness.
  • Targeted results: exosomes contain specific instructions that address skin concerns (such as wrinkles, scars, and pigmentation), resulting in more tailored outcomes.
  • Reduced downtime: recovery time is often shorter than traditional treatments, allowing you to resume your routine sooner.
  • Long-lasting effects: exosome-enhanced microneedling with RF can lead to continuing improvements in your skin’s texture and appearance as time goes on.
  • Customised approach: exosome treatment can be tailored to suit your skin’s needs, maximising your benefits.
  • Natural approach: exosomes work harmoniously with your body’s natural processes, promoting skin health in a natural way.
microneeding RF exosomes before and after
Microneedling RF with exosomes significantly improves skin renewal and regeneration.

What to expect after microneedling with exosomes?

Here is what you can anticipate during and after the procedure:

  • Consultation: discuss your concerns and desired results with a skincare specialist; this allows them to tailor the treatment according to your needs.
  • Preparation: numbing cream is usually applied to ensure comfort during the procedure.
  • RF Microneedling: the treatment begins with a specialised device to gently create controlled micro-injuries on your skin’s surface. RF energy is simultaneously delivered to stimulate collagen production.
  • Exosome application: exosomes are applied during or immediately after microneedling to further enhance rejuvenation.
  • Sensations: you may feel mild discomfort during the procedure, but the numbing cream minimises potential pain.
  • Redness: you can expect some redness in certain areas post-treatment, which usually subsides within a few hours.
  • Downtime: while downtime is usually minimal, avoiding makeup and sun exposure for the first two days following the procedure is recommended.
  • Results: over time, you will notice improvements in skin texture, tone, and appearance as collagen remodelling takes effect.

Each individual experience varies. It is important to discuss your expectations with a qualified professional to ensure you are receiving personalised and comfortable treatment tailored to your needs, concerns, and desired results.

Safety considerations and possible side effects of microneedling RF with exosomes

Prioritising safety is crucial when considering exosome-enhanced microneedling RF. While this treatment is generally safe and effective, there are essential factors to take note of to ensure a positive experience.

The expertise of the professional performing the procedure is of utmost importance. Opting for a trained and certified skincare specialist guarantees proper execution of the procedure and significantly reduces the likelihood of any complications arising.

It is crucial to understand that everyone’s skin reacts differently to treatments. While most individuals experience minimal side effects such as temporary redness, swelling, or mild discomfort, your skin may respond to this treatment differently.

Rare risks (though very uncommon) are potential considerations. These risks include infection, scarring, or alterations in pigmentation. However, selecting a reputable and experienced professional substantially mitigates these risks, assuring a safer procedure overall. You must also disclose any allergies or sensitivities to your practitioner, as this information enables them to tailor the treatment and avoid adverse reactions to exosomes or other products used during the procedure.

Adhering to aftercare instructions provided by your professional is crucial. These guidelines are essential in optimising the healing process and ensuring you achieve your desired results.

Who is a suitable candidate for microneedling RF with exosomes?

This treatment is suitable for a wide range of individuals seeking skin rejuvenation and improvement. You may benefit from this procedure if you have fine lines and wrinkles, acne scars, pigmentation, and uneven skin tone or texture.

Generally, you should be healthy and have realistic expectations about the potential outcomes. Whether you have light or dark skin, exosome-enhanced microneedling can be tailored to suit your needs. However, it is best to consult your skincare specialist before proceeding if you have active skin infections, severe skin conditions, or certain medical conditions.

A personalised consultation will determine if this procedure is right for you. A skincare professional will consider your skin type, concerns, medical history, and goals to create a treatment plan that is safe and effective, ensuring you achieve your desired results.

fine lines and wrinkles
Microneedling RF with exosomes efficiently treats fine lines and wrinkles.

Can you combine exosome with other aesthetic treatments?

You can enhance your results by combining exosome therapy with other aesthetic treatments. This approach, often called combination therapy, can provide even more comprehensive improvements for your skin.

For instance, laser treatments are commonly done with exosome therapy to further improve and address surface texture irregularities and pigmentation issues.

Additionally, treatments like dermal fillers and/or BTX can complement exosome-enhanced microneedling by targeting different aspects of ageing, such as volume loss and wrinkles from hyperactive muscle facial movements.

However, it is crucial to work closely with your skincare professional to create a tailored plan that meets your unique needs. They will ensure the treatments are compatible and administered to maximise your benefits. With the right combination of treatments, you can achieve a more complete and harmonious rejuvenation for your skin.

smooth skin
A licensed and experienced skin specialist will work closely with you to meet your skin needs and desires.


In conclusion, exosome-enhanced microneedling presents an exciting avenue for achieving revitalised and more youthful skin. By harnessing the power of exosomes and combining it with microneedling and RF technology, you open the door to a natural and effective approach to cell regeneration and skin rejuvenation. Consulting with a qualified professional will help you explore this innovative treatment and embark on a journey towards healthier, more radiant skin.


  1. Trott, M. (2022, September 15). Exosomes: Definition, Function and Use in Therapy. Retrieved from Technology Networks Cell Science:
  2.  Sathish Muthu, A. B. (2021). Exosomal therapy—a new frontier in regenerative medicine. Stem Cell Investigation, doi: 10.21037/sci-2020-037.
  3. Abhimanyu Thakur, D. S. (2023). Therapeutic Values of Exosomes in Cosmetics, Skin Care, Tissue Regeneration, and Dermatological Diseases. Cosmetics MDPI,
  4. Marcus G Tan, C. E. (2021). Radiofrequency Microneedling: A Comprehensive and Critical Review. Dermatologic Surgery, 755-761.
  5. Grace K A, S. L. (2022). Evaluating the effectiveness and safety of radiofrequency for face and neck rejuvenation: A systemic review. Lasers in Surgery and Medicine, 27-45.
  6. Patricia K F, T. L. (2022). Exosomes: The Next Big Thing in Skincare? Skincare Science.
  7. Gyeong-Hun Park, H. H. (2023). Efficacy of combined treatment with human adipose tissue stem cell-derived exosome-containing solution and microneedling for facial skin aging: A 12-week prospective, randomized, split-face study. Journal of Cosmetic Dermatology,